I am easily side-tracked.
But something interesting, a hangover is caused by the lack of water in your TCA CYCLE. 🙂
According to studies, drinking about 250 milliliters of an alcoholic beverage causes the body to expel 800 to 1,000 milliliters of water; that’s four times as much liquid lost as gained. This diuretic effect decreases as the alcohol in the bloodstream decreases, but the aftereffects help create a hangover.
The morning after heavy drinking, the body sends a desperate message to replenish its water supply — usually manifested in the form of an extremely dry mouth. Headaches result from dehydration because the body’s organs try to make up for their own water loss by stealing water from the brain, causing the brain to decrease in size and pull on the membranes that connect the brain to the skull, resulting in pain.
Ethanol is converted to acetaldehyde by the enzyme alcohol dehydrogenase, and then from acetaldehyde to acetic acid by the enzyme acetaldehyde dehydrogenase. Acetaldehyde (ethanal) is mildly toxic, contributing to the hangover. These two reactions also require the conversion of NAD+ to NADH. With an excess of NADH, the lactate dehydrogenase reaction is driven to produce lactate from pyruvate (the end product of glycolysis) in order to regenerate NAD+ and sustain life. This diverts pyruvate from other pathways such as gluconeogenesis, thereby impairing the ability of the liver to supply glucose to tissues, especially the brain. Because glucose is the primary energy source of the brain, this lack of glucose contributes to hangover symptoms such as fatigue, weakness, mood disturbances, and decreased attention and concentration.
There are various nervous system effects: the removal of the depressive effects of alcohol in the brain probably account for the light and noise sensitivity.
During the meatbolism of alcohol, one molecule of ethanol (the primary component present in alcoholic beverages) produces 2 molecules of NADH, utilizing Vitamin B12 as a coenzyme. So, over-consumption of ethanol may cause vitamin B12 deficiency as well.
Eggs, Banana, drinking lot of water and fruit juices are excellent remedy for Hangover.